Plasma membrane homing of tissue nonspecific alkaline phosphatase under the influence of 3-hydrogenkwadaphnin, an antiproliferative agent from Dendrostellera lessertii.
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منابع مشابه
Plasma membrane homing of tissue nonspecific alkaline phosphatase under the influence of 3-hydrogenkwadaphnin, an antiproliferative agent from Dendrostellera lessertii.
Several mammalian enzymes are anchored to the outer surface of the plasma membrane by a covalently attached glycosylphosphatidylinositol (GPI) structure. These include acetylcholinesterase, alkaline phosphatase (AP) and 5'-nucleotidase among other enzymes. Recently, it has been reported that these membrane enzymes can be released into the serum by the GPI-dependent phospholipase D under various...
متن کاملThe effect of Dendrostellera lessertii on the cell membrane redistribution of alkalinee phosphatase
Several mammalian enzymes are anchored to the outer surface of plasma membrane by a covalently attached glycosyl-phosphatidylinisitol (GPI) structure. These include acetylcholinesterase, alkalinee phosphatase and 5´-nucleotidase. Recently, it has been reported that these membrane enzymes can be solubilized into the serum by GPI-dependent PLD, under various medical disturbances such as cancer an...
متن کامل3-Hydrogenkwadaphnin from Dendrostellera lessertii induces differentiation and apoptosis in HL-60 cells.
3-Hydrogenkwadaphnin (3-HK) is a new diterpene ester, recently isolated from the leaves of Dendrostellera lessertii with potent anti-tumoral and anti-metastatic activities. Herein, we report that 3-HK induces differentiation and apoptosis in HL-60 cells. The drug at 2.5 - 40 nM inhibited proliferation of HL-60 cells after 24 - 96 h of treatment. Cell viability was also decreased by 57 % after 9...
متن کاملThe effect of Dendrostellera lessertii on the cell membrane redistribution of alkalinee phosphatase
Several mammalian enzymes are anchored to the outer surface of plasma membrane by a covalently attached glycosyl-phosphatidylinisitol (GPI) structure. These include acetylcholinesterase, alkalinee phosphatase and 5´-nucleotidase. Recently, it has been reported that these membrane enzymes can be solubilized into the serum by GPI-dependent PLD, under various medical disturbances such as cancer an...
متن کاملLansoprazole is an uncompetitive inhibitor of tissue-nonspecific alkaline phosphatase.
Lansoprazole, a known H(+)/K(+)-ATPase inhibitor, is currently used as a therapeutical option for the initial treatment of gastroesophageal reflux disease. Recently, lansoprazole has been found to be an inhibitor of cytosolic PHOSPHO1 (a phosphatase which hydrolyses phosphocholine and phosphoethanolamine), providing a possible therapeutical target to cure pathological mineralization. Since PHOS...
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 2007
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.2007_3253